Amendments
DISCLAIMER: The below documentation is intended for the use of NHS Hospital Sites and Ambulance Services open to the SIS trial only.
| Amendment | Description | Approval(s) | Documents |
| SA01 | Update to protocol Version 6.0, 18Jul2024 (ALL SITES) | ||
| SA02 | Change in trial sample size & Amendments to Core Study Documentation (ALL SITES) | ||
| SA03 | Submission of new study documents & Amendments to Core Study Documentation (ALL SITES/WAST) | ||
| NSA02 | Addition of NHS Sites (Bart's, St George's, MKUH, Barking, UCL, Royal Berkshire and Imperial) & Change of PI to existing NHS site (OUH) | Confirmation Email | |
| NSA03 | Addition of NHS Sites (King's College, Salisbury, Epsom & St Helier) | Confirmation Email | Amendment Tool |
| NSA04 | Addition of NHS Sites (London North West NHS Trust) & Change of PI at LAS | Confirmation Email | Amendment Tool |
| NSA05 | Addition of NHS Site (Portsmouth NHS Trust) | Confirmation Email | Amendment Tool |
| NSA06 | Update to Protocol version 4.0, 05Sep2023 (ALL SITES) | Confirmation Email | Amendment Tool |
| NSA07 | Addition of NHS Site (Lewisham and Greenwich) | Confirmation Email | Amendment Tool |
| NSA08 | Update to Protocol version 5.0, 25Oct2023 (ALL SITES) | Confirmation Email | Amendment Tool |
| NSA09 | Addition of NHS Sites (Hampshire Hospitals, Croydon Health, Great Western, Guy's & St Thomas) | Confirmation Email | Amendment Tool |
| NSA10 | Addition of NHS sites (NWAS & IWAS) | Confirmation Email | Amendment Tool |
| NSA11 | Addition of NHS sites (WAST) | Confirmation Email | Amendment Tool |
| NSA12 | Addition of NHS sites (Southport, Countess of Chester, Stockport, NCA Salford) | Confirmation Email | Amendment Tool |
| NSA13 | Addition of NHS collaborator sites (WAST, Aneurin Bevan, Betsi Cadwaladr, Cwn Taf Morgannwg, Cardiff & Vale, Hywel Dda, Swansea Bay) | Confirmation Email | Amendment Tool |
| NSA14 | Addition of NHS sites (Bolton, Liverpool Royal, Aintree) | Confirmation Email | Amendment Tool |
| NSA15 | Addition of new Organisation Information Document (OID) template (Isle of Wight NHS Trust) | Confirmation Email | Amendment Tool |
| NSA16 | PI Change - Epsom and St Helier University Hospitals NHS Trust | Confirmation Email | Amendment Tool |
| NSA17 | Addition of NHS site (Warrington Hospital) | Confirmation Email | Amendment Tool |
| NSA18 | Addition of NHS site (Royal Albert Edward Infirmary) | Confirmation Email | Amendment Tool |
| NSA19 | Addition of NHS site (Manchester Royal Infirmary) | Confirmation Email | Amendment Tool |
| NSA20 | Addition of NHS site (Royal Blackburn Teaching Hospital) | Confirmation Email | Amendment Tool |
| NSA21 |
Trial Documentation translated to Welsh (WELSH SITES) Addition of NHS Site (Blackpool Teaching Hospital) |
Confirmation Email | Amendment Tool |
| NSA22 | Addition of NHS site (Shrewsbury and Telford) | Confirmation Email | Amendment Tool |
| NSA23 | Study end date extension to 30Apr2026 and minor amendment to the protocol. | Confirmation Email | Amendment Tool |
| NSA24 | Change of PI at Salford Royal Hospital | Confirmation Email | Amendment Tool |
| NSA25 | Study end date extension to 28Feb2027 and minor amendment to the protocol. | Confirmation Email | Amendment Tool |