What we do
Example experiments
This page gives a summary of the kind of experiments we can do for you.
Particle size and structure
- Liposomes, vesicles, nanoparticles and micelles
- Size measurements
- Extracellular vesicle imaging compliant with MISEV2023
- Number of membrane layers
- Membrane thickness
- Nanoparticle ultrastructure
Batch-to-batch comparison
- Viruses, bacteriophage and proteins
- Encapsulation
- Payload confirmation (full/empty)
- Purity and stability
- Contamination
- Aggregation
- Phage morphology
Cryo-EM grid optimisation
- Working towards high-resolution structure of biomolecules
- Optimisation of grids for data collection at regional or national cryo-EM facilities
- Refeyn mass photometry
- Negative stain and cryo screening
Cryo-SEM
- Biofilms, hydrogels and plant material
- Surface structure and comparison
- Freeze-fracture cryo-imaging
Conventional TEM
- Ultrastructure of mammalian cells, tissue and micro-organisms
- Organelle morphology
- Analysis of mutants and knockouts
- Nanoparticle localisation
Volume datasets
- Neurobiology, plants, cultured cells, host-microbe interactions, nanoparticle location
- Three-dimensional datasets by array tomography in SEM
- Larger field of view than conventional TEM